The two teams will face off in Bilbao on Wednesday night, each looking to end their campaign with a trophy. United have been unbeaten in the Europa League this season, while Tottenham have been dominant throughout their journey to the final.
Against United this season, Spurs have won three times, including a 3-0 league victory at Old Trafford and a 4-3 win in the EFL Cup quarter-finals. Ferdinand believes that Tottenham's physical strength is a major concern for United.
"The worrying thing for me from a Manchester United perspective is that physically we can't keep up with any team in the Premier League," Ferdinand said. "If they go man-to-man and go toe-to-toe with us, we're at a disadvantage because our players don't have the same level of endurance and power as other teams."
Ferdinand noted that United have struggled against teams with a similar physical profile, such as Rangers, who are a Premier League-like side. He's concerned that Spurs, who have beaten United three times this season, can match United's physicality.
Despite scoring 35 goals in the Europa League, Ferdinand thinks United may struggle to keep up with Spurs' intensity. Manager Ruben Amorim's team looks different when playing European fixtures, and Ferdinand worries that they may collapse against a team that knows how to beat them.