Al-Hilal and Liverpool are also interested in signing Isak, who is a Sweden national team player.
Newcastle are exploring other options in case Isak decides to leave the club. Sesko, who plays for RB Leipzig, has a new contract until 2029 and a buyout clause has been removed.
RB Leipzig is open to selling Sesko if he decides to move to a new club, and a reasonable price will be considered.